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whereRU: Aresty Poster 135 - Effect of Epigallocatechin-3-gallate and Atorvastatin in H1299 Cells by Aresty Posters 2009

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Taken by
Aresty Posters 2009 Aresty Posters 2009
Explore score
1
Size
0.06 Gigapixels
Views
657
Date added
May 20, 2009
Date taken
May 19, 2009
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Title:
Potential Synergistic Inhibitory Effect of Epigallocatechin-3-gallate and Atorvastatin Combination in Lung Cancer Cell Lines
Bridget Huang, Fei Guan, Zhihong Yang, Chung S. Yang

Department of Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey

164 Frelinghuysen Road
Piscataway, N.J. 08854-0789
(732) 445-3400

contact:
Bridget Huang, byhuang@eden.rutgers.edu

Abstract:
The principal green tea polyphenol, epigallocatechin-3-gallate (EGCG), and a member of statins family, atorvastatin (ATST, Lipitor), are two chemopreventive agents known to inhibit cancer cell growth. The mechanisms of actions suggest combinatorial treatments of EGCG and ATST have potential synergistic effect in inhibition of tumor cell proliferation and mobility. We used cell invasion assay as a mean of cell mobility determination and 67-laminin receptor (67LR) silencing small hairpin RNA for examining EGCG cell mobility inhibition mechanism via 67LR. Individual treatment of EGCG showed decreased cell invasion. EGCG and ATST combination treatments may be a more effective strategy in chemoprevention than single treatments.


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