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whereRU: Aresty Poster 60 - Antisense Transcription in Yeast Regulates Gene Expression by Aresty Posters 2009

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Taken by
Aresty Posters 2009 Aresty Posters 2009
Explore score
0.06 Gigapixels
Date added
May 27, 2009
Date taken
May 26, 2009

Previous work has shown that the expression of overlapping non-coding RNA (nc-RNA) is a method of transcriptional repression in Saccharomyces cerevisiae. One example of this form of regulation is the control of the meiosis-specific IME4 gene, in which expression of a non-coding antisense transcript, referred to here as RME2 (Repressor of Meiosis), prevents IME4 (Inducer of Meiosis) expression. Mutational analyses have shown a region within the IME4 ORF is required for repression by RME2. RME2 does not appear to disrupt transcription factor binding in the promoter. A similar model of regulation has also been observed for the gene ZIP2, suggesting that this is a conserved mechanism to control gene expression in yeast.
E-mail: napostol@eden.rutgers.edu Will open in a new tab or window ; Lab URL: beadle.rutgers.edu/vershon/Vershon_Lab.html Will open in a new tab or window

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